After the Mousekewitz family settled in the United States for a period of time, they found themselves still facing the threat of cats. This made them eager to try another home in the west, where they received a promise of peaceful life for mice and cats. Unfortunately, the person who made this claim was a greasy scammer named Cat R. Waul, who was planning to carry out his evil plan. Without realizing this, the Mousekewitz family embarked on their western journey, with their true cat friend Tiger following closely and planning to follow his girlfriend in the same direction.