Lucas Cano (Machete) is a former bodyguard of the Mexican president who, tired of his lifestyle, retires to a remote town in Mexico hoping to find peace. But things didn't develop as he hoped. Firstly, he must confront several drug traffickers who smuggle illegal immigrants into the United States, forcing them to smuggle drugs. Then, Machete discovered that his Vietnamese old friend, who was currently working for the Central Intelligence Agency in Arizona, was assigned to arrest Machete and bring him back to the United States on some old charges. Machete's health condition is rapidly deteriorating. He has been bleeding inside, but he won't stop drinking and smoking. Panchito is a little boy that Machete encounters during a street fight. The boy claims to have no family and decides to go out and play with Machete, trying to help him change his lifestyle. Machete didn't know that there was a higher power watching him. Panchito is an angel sent by God to save his body and soul. Pelancho met with Machete...